Nardosinane sesquiterpenoids from the Formosan soft coral Lemnalia flava.
نویسندگان
چکیده
Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava. The structures of the new metabolites were determined by extensive spectroscopic analysis, and the structure of 2 was confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway to 1 and 2 is proposed. Compound 1 was found to display dose-dependent inhibition of iNOS protein expression, and 1 and 2 were shown to possess significant neuroprotective activity.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of natural products
دوره 74 2 شماره
صفحات -
تاریخ انتشار 2011